Original paper
Mitochondrial stress response triggered by defects in protein synthesis quality control
Abstract
Mitochondria have a compartmentalized gene expression system dedicated to the synthesis of membrane proteins essential for oxidative phosphorylation. Responsive quality control mechanisms are needed to ensure that aberrant protein synthesis does not disrupt mitochondrial function. Pathogenic mutations that impede the function of the mitochondrial matrix quality control protease complex composed of AFG3L2 and paraplegin cause a multifaceted...
Paper Details
Title
Mitochondrial stress response triggered by defects in protein synthesis quality control
Published Date
Jan 25, 2019
Journal
Volume
2
Issue
1
Pages
e201800219 - e201800219
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Notes
History