An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Abstract
Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors via a scaffold hopping approach, we have synthesized a series of analogues possessing an isoquinoline ring system. Lead compound 6l binds in the v-shaped pocket at the IN dimer interface and is highly selective for promoting higher-order...
Paper Details
Title
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
Published Date
Jan 30, 2019
Volume
10
Issue
2
Pages
215 - 220
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