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Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components

Published on Feb 11, 2019in PLOS Computational Biology
· DOI :10.1371/journal.pcbi.1006769
Nicholas Rogers1
Estimated H-index: 1
(UCSD: University of California, San Diego),
John Hermiz3
Estimated H-index: 3
(UCSD: University of California, San Diego)
+ 11 AuthorsVikash Gilja21
Estimated H-index: 21
(UCSD: University of California, San Diego)
Cite
Abstract
Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated microelectrodes have an advantage that they can be made very small without losing low impedance. This makes them suitable for evaluating the required granularity of ECoG recording in humans and experimental animals. We used two-dimensional (2D) micro-ECoG grids to record intra-operatively in humans and during acute implantations in mouse with separation distance between neighboring electrodes (i.e., pitch) of 0.4 mm and 0.2/0.25 mm respectively. To assess the spatial properties of the signals, we used the average correlation between electrodes as a function of the pitch. In agreement with prior studies, we find a strong frequency dependence in the spatial scale of correlation. By applying independent component analysis (ICA), we find that the spatial pattern of correlation is largely due to contributions from multiple spatially extended, time-locked sources present at any given time. Our analysis indicates the presence of spatially structured activity down to the sub-millimeter spatial scale in ECoG despite the effects of volume conduction, justifying the use of dense micro-ECoG grids.
  • References (44)
  • Citations (1)
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References44
Newest
Published in Journal of Neuroscience Methods 2.79
Sebastian Michelmann3
Estimated H-index: 3
(University of Birmingham),
Matthias Sebastian Treder18
Estimated H-index: 18
(University of Birmingham)
+ -3 AuthorsStephanie Gollwitzer4
Estimated H-index: 4
Background Intracranial recordings from patients implanted with depth electrodes are a valuable source of information in neuroscience. They allow for the unique opportunity to record brain activity with high spatial and temporal resolution. A common pre-processing choice in stereotactic EEG (S-EEG) is to re-reference the data with a bipolar montage. In this, each channel is subtracted from its neighbor, to reduce commonalities between channels and isolate activity that is spatially confined. New...
Published on Aug 1, 2018in NeuroImage 5.81
John Hermiz3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Nicholas Rogers1
Estimated H-index: 1
(UCSD: University of California, San Diego)
+ 7 AuthorsVikash Gilja21
Estimated H-index: 21
(UCSD: University of California, San Diego)
Abstract Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment of neurological disorders. Recent advances in device engineering are poised to enable orders of magnitude increase in the resolution of ECoG without comprised measurement qu...
Published on Mar 1, 2018in Advanced Functional Materials 15.62
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Erik Kaestner5
Estimated H-index: 5
(UCSD: University of California, San Diego)
+ 15 AuthorsGarth Rees Cosgrove2
Estimated H-index: 2
(Brigham and Women's Hospital)
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based inte...
Published on Nov 1, 2017in Advanced Functional Materials 15.62
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Ahmed T. Elthakeb2
Estimated H-index: 2
(UCSD: University of California, San Diego)
+ 3 AuthorsShadi A. Dayeh31
Estimated H-index: 31
(UCSD: University of California, San Diego)
Reduced contact size would permit higher resolution cortical recordings, but the effects of diameter on crucial recording and stimulation properties are poorly understood. Here, the first systematic study of scaling effects on the electrochemical properties of metallic Pt and Au and organic poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) electrodes is presented. PEDOT:PSS exhibits better faradaic charge transfer and capacitive charge coupling than metal electrodes, and these c...
Published on Nov 1, 2017in Advanced Functional Materials 15.62
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Atsunori Tanaka6
Estimated H-index: 6
(UCSD: University of California, San Diego)
+ 2 AuthorsShadi A. Dayeh31
Estimated H-index: 31
(UCSD: University of California, San Diego)
The efficacy of electrical brain stimulation in combatting neurodegenerative diseases and initiating function is expected to be significantly enhanced with the development of smaller scale microstimulation electrodes and refined stimulation protocols. These benefits cannot be realized without a thorough understanding of scaling effects on electrochemical charge injection characteristics. This study fabricates and characterizes the electrochemical stimulation capabilities of Au, Pt, poly(3,4-ethy...
Published on Oct 1, 2017in Journal of Neural Engineering 4.55
Xi Wang4
Estimated H-index: 4
,
C. Alexis Gkogkidis2
Estimated H-index: 2
+ 7 AuthorsTonio Ball24
Estimated H-index: 24
(University of Freiburg)
Published on Oct 1, 2017in Cell Reports 7.82
Ana Parabucki1
Estimated H-index: 1
(Weizmann Institute of Science),
Ilan Lampl19
Estimated H-index: 19
(Weizmann Institute of Science)
Summary Local field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker-evoked LFP signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conduction signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few ...
Published on Dec 15, 2016in Frontiers in Neural Circuits 3.10
Oscar Herreras30
Estimated H-index: 30
(Cajal Institute)
The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confounding factors and technical limitations. By and large, the main factor defining the amplitude of LFPs is the geometry of the current sources, over and above the degree of synchronizat...
Published on Dec 1, 2016in Advanced Healthcare Materials 6.27
Ilke Uguz9
Estimated H-index: 9
('ENS Paris': École Normale Supérieure),
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego)
+ 9 AuthorsChristophe Bernard37
Estimated H-index: 37
(AMU: Aix-Marseille University)
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
Published on Nov 1, 2016 in ASILOMAR (Asilomar Conference on Signals, Systems and Computers)
Kevin O'Neill1
Estimated H-index: 1
(ASU: Arizona State University),
Paul A. House14
Estimated H-index: 14
(UofU: University of Utah),
Bradley Greger19
Estimated H-index: 19
(ASU: Arizona State University)
The cortex is composed of cortical columns which act as functional compute units in the brain. Epicortical micro-scale electrodes allow experimenters to study these cortical columns and how their activity relates to behavior. Here, we present mesoscale analysis between primary language areas during simple language production. We observed meso-scale spatial and temporal patterns of coupling that correlated with spoken words.