Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin

Insulin secretion is insufficient in cystic fibrosis (CF), even before diabetes is present, though the mechanisms involved remain unclear. Acyl-ghrelin (AG) can diminish insulin secretion and is elevated in humans with CF.We tested the hypothesis that elevated AG contributes to reduced insulin secretion and hyperglycemia in CF ferrets.Fasting AG was elevated in CF versus non-CF ferrets. Similar to its effects in other species, AG administration...