Sex differences in Prostaglandin E2-dependent homeostasis in aspirin-exacerbated respiratory disease

Aspirin-exacerbated respiratory disease (AERD), a triad of late-onset asthma, chronic rhinosinusitis with nasal polyposis and respiratory reactions to inhibitors of cyclooxygenase-1, disproportionately affects females. Impairments in prostaglandin (PG)E2, a known regulator of leukotriene (LT) production and mast cell activation, are implicated in the pathobiology of AERD. Self-reported clinical characteristics from subjects with AERD enrolled in...