Contribution of Liver Fat to Weight Loss–Induced Changes in Serum Hepatokines: A Randomized Controlled Trial

Hepatokines have emerged as potential mediators of obesity-associated comorbidities, such as type 2 diabetes, cardiovascular disease, fractures, and central hypogonadism. To assess whether weight loss–induced changes in hepatokines are mediated by intrahepatic triglyceride (IHTG) content. Cross-sectional study and randomized controlled trial. General community. Metabolically healthy, lean men (waist <94 cm; n = 25) and men with abdominal obesity...