Reference range determination for imaging biomarkers: Myocardial T₁

Background Imaging biomarkers, such as the T 1 relaxation time of the myocardium using MRI, can be valuable in cardiac medicine if they are properly validated. Consensus statements recommend that for myocardial T 1 , each investigator should establish a reference range. Purpose To describe a statistically valid method for determining and reporting the reference range in each center, which simultaneously minimizes the twin risks of undersampling,...