Molecular modelling and simulation of fusion-based amorphous drug dispersions in polymer/plasticizer blends
Abstract
A realistic molecular description of amorphous drug-polymer-plasticizer matrices, suitable for the preparation of amorphous solid dispersions (ASDs) with the aid of fusion-based techniques, was evaluated. Specifically, the incorporation of two model drugs (i.e. ibuprofen, IBU, and carbamazepine, CBZ) having substantially different thermal properties and glass forming ability, on the molecular representation of polyvinyl caprolactam–polyvinyl...
Paper Details
Title
Molecular modelling and simulation of fusion-based amorphous drug dispersions in polymer/plasticizer blends
Published Date
Mar 1, 2019
Volume
130
Pages
260 - 268
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