Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology
Abstract
The objective of this study was to develop diazepam orally disintegrating tablets and to optimize tablets characteristics using response surface methodology (RSM). Tablets were prepared by direct compression of mixture containing mannitol, copovidone, crosspovidone flavor and lubricant. A full factorial design for 2 factors at 3 levels each was applied to investigate the influence of 2 formulation variables on the mechanical strength/hardness,...
Paper Details
Title
Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology
Published Date
Jan 1, 2005
Volume
51
Pages
15 - 22
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