Tumour-reactive T cell subsets in the microenvironment of ovarian cancer

Solid malignancies are frequently infiltrated with T cells. The success of adoptive cell transfer (ACT) with expanded tumour-infiltrating lymphocytes (TILs) in melanoma warrants its testing in other cancer types. In this preclinical study, we investigated whether clinical-grade TILs could be manufactured from ovarian cancer (OC) tumour specimens.Thirty-four tumour specimens were obtained from 33 individual patients with OC. TILs were analysed...