Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells
Abstract
Selective differentiation of naive T cells into multipotent T cells is of great interest clinically for the generation of cell-based cancer immunotherapies. Cellular differentiation depends crucially on division state and time. Here we adapt a dye dilution assay for tracking cell proliferative history through mass cytometry and uncouple division, time and regulatory protein expression in single naive human T cells during their activation and...
Paper Details
Title
Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells
Published Date
Feb 11, 2019
Journal
Volume
37
Issue
3
Pages
259 - 266
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