Interleukin-33 prevents the development of autoimmune diabetes in NOD mice
Abstract
IL-33/ST2 signal is important for the generation of forkhead box P3 (Foxp3)+ regulatory (Treg) cells, which contribute to immune homeostasis in the context of diseases. The aim of this study was to determine whether targeting IL-33/ST2 signal could establish immunological tolerance and prevent type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. Female NOD mice treated with IL-33 for 4 weeks decreased the incidence and delayed the onset of...
Paper Details
Title
Interleukin-33 prevents the development of autoimmune diabetes in NOD mice
Published Date
May 1, 2019
Volume
70
Pages
9 - 15
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