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“Dorsal–Ventral” Genes Are Part of an Ancient Axial Patterning System: Evidence from Trichoplax adhaerens (Placozoa)

Published on May 1, 2019in Molecular Biology and Evolution 14.80
· DOI :10.1093/molbev/msz025
Timothy Q. DuBuc7
Estimated H-index: 7
(UF: University of Florida),
Joseph F. Ryan22
Estimated H-index: 22
(UF: University of Florida),
Mark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
  • References (82)
  • Citations (1)
Published on Oct 30, 2018in eLife 7.55
Christopher E Laumer1
Estimated H-index: 1
(EMBL-EBI: European Bioinformatics Institute),
Harald R. Gruber-Vodicka10
Estimated H-index: 10
(MPG: Max Planck Society)
+ 4 AuthorsGonzalo Giribet60
Estimated H-index: 60
(Harvard University)
Filter-feeding sponges and tiny gliding, pancake-like animals called placozoans are the only two major groups of animals that lack muscles, nerves and an internal gut. Sponges have historically been seen as the first to have branched off in animal phylogeny – the family tree of living organisms that shows how species are related. This is because it is assumed that they split from the other animals before features including muscles, nerves and internal guts evolved. Sequences of their genetic mat...
Published on Jul 31, 2018in PLOS Biology
Michael Eitel13
Estimated H-index: 13
(University of Veterinary Medicine Hanover),
Warren R. Francis8
Estimated H-index: 8
(LMU: Ludwig Maximilian University of Munich)
+ 8 AuthorsBernd Schierwater34
Estimated H-index: 34
(University of Veterinary Medicine Hanover)
Placozoans are a phylum of nonbilaterian marine animals currently represented by a single described species, Trichoplax adhaerens, Schulze 1883. Placozoans arguably show the simplest animal morphology, which is identical among isolates collected worldwide, despite an apparently sizeable genetic diversity within the phylum. Here, we use a comparative genomics approach for a deeper appreciation of the structure and causes of the deeply diverging lineages in the Placozoa. We generated a high-qualit...
Published on Nov 1, 2018in Current Biology 9.19
Frederique Varoqueaux38
Estimated H-index: 38
(UNIL: University of Lausanne),
E. Williams13
Estimated H-index: 13
(University of Exeter)
+ 5 AuthorsDirk Fasshauer40
Estimated H-index: 40
(UNIL: University of Lausanne)
Placozoans, together with sponges, are the only animals devoid of a nervous system and muscles, yet both respond to sensory stimulation in a coordinated manner. How behavioral control in these free-living animals is achieved in the absence of neurons and, more fundamentally, how the first neurons evolved from more primitive cells for communication during the rise of animals are not yet understood [1-5]. The placozoan Trichoplax adhaerens is a millimeter-wide, flat, free-living marine animal comp...
Published on Jul 1, 2018in Nature Ecology and Evolution
Arnau Sebé-Pedrós16
Estimated H-index: 16
(Weizmann Institute of Science),
Elad Chomsky8
Estimated H-index: 8
(Weizmann Institute of Science)
+ 7 AuthorsAmos Tanay43
Estimated H-index: 43
(Weizmann Institute of Science)
A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement cell-type-specific functions. However, the evolution of metazoan cell types and their underlying gene regulatory programmes remains largely uncharacterized. Here, we use whole-organism single-cell RNA sequencing to map cell-type-specific transcription in Porifera (sponges), Ctenophora (comb jellies) and Placozoa species. We describe the repertoires of cell types in these non-bilaterian animals, uncovering dive...
Published on Jan 4, 2018in Nucleic Acids Research 11.15
Ivica Letunic46
Estimated H-index: 46
Peer Bork170
Estimated H-index: 170
(EMBL-EBI: European Bioinformatics Institute)
Published on Dec 1, 2017in Current Biology 9.19
Olga Baron7
Estimated H-index: 7
('KCL': King's College London),
Adel Boudi2
Estimated H-index: 2
('KCL': King's College London)
+ 9 AuthorsRoland A. Fleck12
Estimated H-index: 12
('KCL': King's College London)
The terminal stages of neuronal degeneration and death in neurodegenerative diseases remain elusive. Autophagy is an essential catabolic process frequently failing in neurodegeneration. Selective autophagy routes have recently emerged, including nucleophagy, defined as degradation of nuclear components by autophagy. Here, we show that, in a mouse model for the polyglutamine disease dentatorubral-pallidoluysian atrophy (DRPLA), progressive acquirement of an ataxic phenotype is linked to severe ce...
Published on Apr 1, 2017in Current Biology 9.19
Paul Simion2
Estimated H-index: 2
(University of Paris),
Hervé Philippe79
Estimated H-index: 79
(UdeM: Université de Montréal)
+ 13 AuthorsAlexander V. Ereskovsky24
Estimated H-index: 24
Resolving the early diversification of animal lineages has proven difficult, even using genome-scale datasets. Several phylogenomic studies have supported the classical scenario in which sponges (Porifera) are the sister group to all other animals (''Porifera-sister''3 hypothesis), consistent with a single origin of the gut, nerve cells, and muscle cells in the stem lineage of eumetazoans (bilaterians + ctenophores + cnidarians). In contrast, several other studies have recovered an alternative t...
Published on Dec 1, 2016in The Biological Bulletin 1.54
Carolyn L. Smith51
Estimated H-index: 51
Thomas S. Reese56
Estimated H-index: 56
AbstractTrichoplax adhaerens is the sole named member of Placozoa, an ancient metazoan phylum. This coin-shaped animal glides on ventral cilia to find and digest algae on the substrate. It has only six cell types, all but two of which are incorporated into the epithelium that encloses it. The upper epithelium is thin, composed of a pavement of relatively large polygonal disks, each bearing a cilium. The lower epithelium is thick and composed primarily of narrow ciliated cells that power locomoti...
Cited By1
Published in Royal Society Open Science 2.52
Claus Nielsen33
Estimated H-index: 33
(Wild Center)
Two hypotheses for the early radiation of the metazoans are vividly discussed in recent phylogenomic studies, the ‘Porifera-first’ hypothesis, which places the poriferans as the sister group of all...
Published on Jul 3, 2019in Cell and Tissue Research 3.36
Carolyn L. Smith51
Estimated H-index: 51
(NIH: National Institutes of Health),
Tatiana D. Mayorova1
Estimated H-index: 1
(NIH: National Institutes of Health)
Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface. Here we review recent work on the phenotypes of its six cell types and their roles in digestion and feeding behavior. Phylogenomic analyses place Placozoa as sister to Eumetazoa, the clade that includes Cnidaria and Bilater...