Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile
Abstract
Strains of Clostridioides difficile cause detrimental diarrheas with thousands of deaths worldwide. The infection process by the Gram-positive, strictly anaerobic gut bacterium is directly related to its unique metabolism, using multiple Stickland-type amino acid fermentation reactions coupled to Rnf complex-mediated sodium/proton gradient formation for ATP generation. Major pathways utilize phenylalanine, leucine, glycine and proline with the...
Paper Details
Title
Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile
Published Date
Feb 15, 2019
Journal
Volume
10
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