CasX enzymes comprise a distinct family of RNA-guided genome editors
Abstract
The RNA-guided CRISPR-associated (Cas) proteins Cas9 and Cas12a provide adaptive immunity against invading nucleic acids, and function as powerful tools for genome editing in a wide range of organisms. Here we reveal the underlying mechanisms of a third, fundamentally distinct RNA-guided genome-editing platform named CRISPR-CasX, which uses unique structures for programmable double-stranded DNA binding and cleavage. Biochemical and in vivo data...
Paper Details
Title
CasX enzymes comprise a distinct family of RNA-guided genome editors
Published Date
Feb 1, 2019
Journal
Volume
566
Issue
7743
Pages
218 - 223
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