Anti-tumour immunity controlled through mRNA m 6 A methylation and YTHDF1 in dendritic cells
Abstract
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2. Despite the presence of numerous neoantigens in patients, complete tumour elimination is rare, owing to failures in mounting a sufficient and lasting antitumour immune response3,4. Here we show that durable neoantigen-specific immunity is regulated by mRNA...
Paper Details
Title
Anti-tumour immunity controlled through mRNA m 6 A methylation and YTHDF1 in dendritic cells
Published Date
Feb 6, 2019
Journal
Volume
566
Issue
7743
Pages
270 - 274
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