The Effect of Dopamine Antagonist Treatment on Auditory Verbal Hallucinations in Healthy Individuals Is Clearly Influenced by COMT Genotype and Accompanied by Corresponding Brain Structural and Functional Alterations: An Artificially Controlled Pilot Study

Few studies have been conducted to explore the influence of the COMT genotype on the severity and treatment effect of auditory verbal hallucinations symptoms (AVHs) in healthy individuals with AVHs (H-AVHs) subjects. We hypothesized that the effect of dopamine antagonist treatment on AVHs in H-AVHs may be influenced by their catechol-o-methyl transferase (COMT) genotype and may be accompanied by corresponding brain alterations. To preliminary...