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Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: A cross-sectional study

Published on Jul 1, 2019in Nutrition3.591
· DOI :10.1016/j.nut.2019.01.005
B.H. Khor2
Estimated H-index: 2
(UKM: National University of Malaysia),
Sharmela Sahathevan4
Estimated H-index: 4
(UKM: National University of Malaysia)
+ 12 Authorsfor PaTCH Investigators
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Abstract
Abstract Objectives The aims of this study were threefold: first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whether blood FAs could serve as a biomarker of dietary fat intake quality in these patients. Methods Using 3 d of dietary records, FA intakes of 333 recruited patients were calculated using a food database built from laboratory analyses of commonly consumed Malaysian foods. Plasma triacylglycerol (TG) and erythrocyte FAs were determined by gas chromatography. Results High dietary saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) consumption trends were observed. Patients on HD also reported low dietary ω-3 and ω-6 polyunsaturated fatty acid (PUFA) consumptions and low levels of TG and erythrocyte FAs. TG and dietary FAs were significantly associated respective to total PUFA, total ω-6 PUFA, 18:2 ω-6, total ω-3 PUFA, 18:3 ω-3, 22:6 ω-3, and trans 18:2 isomers (P Conclusion TG and erythrocyte FAs serve as biomarkers of dietary PUFA intake in patients on HD. Elevation of circulating MUFA may be attributed to inadequate intake of PUFAs.
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References43
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#1Ban Hock Khor (UKM: National University of Malaysia)H-Index: 1
#2Karuthan Chinna (Taylors University)H-Index: 2
Last. Tilakavati Karupaiah (Taylors University)H-Index: 9
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Background This study aimed to assess the situational capacity for nutrition care delivery in the outpatient hemodialysis (HD) setting in Malaysia by evaluating dietitian accessibility, nutrition practices and patients’ outcomes.
1 CitationsSource
#1Ban Hock Khor (UKM: National University of Malaysia)H-Index: 1
#2Sreelakshmi Sankara Narayanan (Taylors University)H-Index: 1
Last. Tilakavati KarupaiahH-Index: 9
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Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onward...
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#1Ban Hock Khor (UKM: National University of Malaysia)H-Index: 1
#2Sreelakshmi Sankara Narayanan (UKM: National University of Malaysia)H-Index: 1
Last. Tilakavati KarupaiahH-Index: 9
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Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed to assess the efficacy of different nutritional interventions at improving inflammatory outcomes in HD patients, based on markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour nec...
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Alpha-linolenic acid (ALA) is an essential fatty acid and the substrate for the synthesis of longer-chain, more unsaturated ω-3 fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid and docosahexaenoic acid (DHA). EPA and DHA are associated with human health benefits. The primary source of EPA and DHA is seafood. There is a need for sustainable sources of biologically active ω-3 fatty acids. Certain plants contain high concentrations of ALA and stearidonic acid (SDA). Here we review th...
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Background and Objectives Protein energy wasting and systemic inflammation are prevalent in maintenance hemodialysis (MHD) patients. Omega-3 ( ω -3) fatty acids have anti-inflammatory properties and have been shown to improve protein homeostasis. We hypothesized that administration of high-dose (2.9 g/d) ω -3 would be associated with decreased muscle protein breakdown in MHD patients with systemic inflammation. Design, setting, participants & measurements This is a substudy from a randomized, pl...
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Background The multiple dietary restrictions recommended to hemodialysis patients may be difficult to achieve and, at the same time, may result in nutritional deficiencies rendering a poor dietary quality. We here assess the dietary quality and adherence to renal-specific guideline recommendations among hemodialysis patients from a single center in Canary Islands, Spain. Methods Cross-sectional study, including 91 patients undergoing maintenance hemodialysis. Clinical data and 3-day dietary reco...
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#1Je Min LeeH-Index: 14
#2Hyungjae LeeH-Index: 14
Last. Woo Jung ParkH-Index: 1
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Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human health and development, and numerous fatty acid desaturases play key roles in synthesizing PUFAs. Given the lack of delta-12 and -15 desaturases and the low levels of conversion to PUFAs, humans must consume some omega-3 and omega-6 fatty acids in their diet. Many studies on fatty acid desaturases as well as PUFAs have shown that fatty acid desaturase genes are closely related to different human physiol...
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#1Sharmela Sahathevan (UKM: National University of Malaysia)H-Index: 4
#2Chee Hee Se (UKM: National University of Malaysia)H-Index: 4
Last. Tilakavati Karupaiah (UKM: National University of Malaysia)H-Index: 9
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Background Poor appetite could be indicative of protein energy wasting (PEW) and experts recommend assessing appetite in dialysis patients. Our study aims to determine the relationship between PEW and appetite in haemodialysis (HD) patients.
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Background n-3 polyunsaturated fatty acids (PUFAs) might be useful nutritional strategy for treating patients with sarcopenia. We evaluated the effect of the intake of dietary n-3 PUFAs on the skeletal muscle mass (SMM), appendicular skeletal muscle mass (ASM), and its determinants in patients receiving standard hemodialysis (HD) treatment for the management of end stage renal disease. Methods In this cross-sectional study, data of 111 HD patients were analyzed. Anthropometric and bioelectrical ...
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#1Rajiv SaranH-Index: 50
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Author(s): Saran, R; Li, Y; Robinson, B; Ayanian, J; Balkrishnan, R; Bragg-Gresham, J; Chen, JTL; Cope, E; Gipson, D; He, K; Herman, W; Heung, M; Hirth, RA; Jacobsen, SS; Kalantar-Zadeh, K; Kovesdy, CP; Leichtman, AB; Lu, Y; Molnar, MZ; Morgenstern, H; Nallamothu, B; O'Hare, AM; Pisoni, R; Plattner, B; Port, FK; Rao, P; Rhee, CM; Schaubel, DE; Selewski, DT; Shahinian, V; Sim, JJ; Song, P; Streja, E; Kurella Tamura, M; Tentori, F; Eggers, PW; Agodoa, LYC; Abbott, KC
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