Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes
Abstract
The heterozygous DQ2/8 (DQA1*05:01-DQB1*02:01/DQA1*03:01-DQB1*03:02) genotype confers the highest risk in type 1 diabetes (T1D), whereas the DQ6/8 (DQA1*02:01-DQB1*06:02/DQA1*03:01-DQB1*03:02) genotype is protective. The mechanism of dominant protection by DQ6 (DQB1*06:02) is unknown. We tested the hypothesis that DQ6 interferes with peptide binding to DQ8 by competition for islet epitope (“epitope stealing”) by analysis of the islet ligandome...
Paper Details
Title
Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes
Published Date
Jan 9, 2019
Journal
Volume
68
Issue
4
Pages
787 - 795
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