A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis
Abstract
Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL) and B‐cell activation factor (BAFF) are currently targeted in autoimmune diseases as B‐cell regulators. In multiple sclerosis (MS), combined APRIL/BAFF blockade led to unexpected exacerbated inflammation in the central nervous system (CNS) of patients. Here, we investigate the role of the APRIL/BAFF axis in the CNS. Methods APRIL expression was...
Paper Details
Title
A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis
Published Date
Feb 4, 2019
Journal
Volume
85
Issue
3
Pages
406 - 420
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