A Framework Linking Glycolytic Metabolic Capabilities and Tumor Dynamics

Metabolic reprogramming is a hallmark of cancer. The main aim of this paper is to integrate a genome-scale metabolic description of tumor cells into a tumor growth model that accounts for the spatiotemporally heterogeneous tumor microenvironment, in order to study the effects of microscopic characteristics on tumor evolution. A lactate maximization metabolic strategy that allows near-optimal growth solution, while maximizing lactate secretion,...