Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes
Abstract
Keloid is a dermal proliferative disorder characterized by the excessive proliferation and migration of keratinocytes and fibroblasts. Over-activation of the serine/threonine protein kinase, mammalian target of rapamycin (mTOR), plays a pivotal role in the process. Here, we show that both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) were hyper-activated in keloid-derived primary keratinocytes. Further, OSI-027, an mTOR kinase inhibitor,...
Paper Details
Title
Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes
Published Date
Feb 12, 2019
Journal
Volume
28
Issue
3
Pages
270 - 275
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Notes
History