Original paper
Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
Abstract
Immune checkpoint blockade therapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses due to insufficient T cell infiltration in tumors. Here we show that expression of mitochondrial uncoupling protein 2 (UCP2) in tumor cells determines the immunostimulatory feature of the tumor microenvironment (TME) and is positively associated with prolonged survival. UCP2 reprograms the immune state of...
Paper Details
Title
Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
Published Date
Jan 21, 2019
Journal
Volume
20
Issue
2
Pages
206 - 217
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Notes
History