Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
Abstract
Intestinal and free-living protozoa, such as Giardia lamblia , express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine. Here we show that VSPs not only are resistant to proteolytic digestion and extreme pH and temperatures but also stimulate host innate immune responses in a TLR-4 dependent manner. We show that these properties can be exploited to both protect and...
Paper Details
Title
Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
Published Date
Jan 21, 2019
Journal
Volume
10
Issue
1
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