Anti-inflammatory norabietane diterpenoids from the leaves of Salvia officinalis L.

As an aromatic plant of the Labiatae family, Salvia officinalis L. (sage), is cultured worldwide, especially in Mediterranean region. The leaves of sage are used as a popular herbal tea, drug and seasoning. In the present study, eight novel C20-norabietane diterpenoids (salofficinoids A-H, 1–8), along with four known analogues (9–12) which were responsible for the anti-inflammatory activity, were purified from the sage leaves via bioassay-guided...