The inhibitory effects of flavonoids on α-amylase and α-glucosidase

The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of acarbose (Aca). Flavonoids reported to be more effective at inhibiting αG than Aca have been summarized. The concept of “relative coefficient to Aca (RCAca)” has been proposed to integrate data from various reports. Correlations between hydrogen bond donors...