The effect of mutant GBA1 on accumulation and aggregation of α-synuclein
Abstract
Gaucher disease (GD) patients and carriers of GD mutations have a higher propensity to develop Parkinson’s disease (PD) in comparison to the non-GD population. This implies that mutant GBA1 allele is a predisposing factor for the development of PD. One of the major characteristics of PD is the presence of oligomeric α-synuclein-positive inclusions known as Lewy bodies in the dopaminergic neurons localized to the substantia nigra pars compacta....
Paper Details
Title
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein
Published Date
Jan 7, 2019
Journal
Volume
28
Issue
11
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