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Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.

Published on Jan 9, 2019in Veterinary Sciences
· DOI :10.3390/vetsci6010004
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
Cite
Abstract
Heat stress has been related to the impairment of behavioral and immunological parameters in broiler chickens. However, the literature is not clear on the involvement of neuroimmune interactions in a heat stress situation associated with bacterial and parasitic infections. The present study evaluated the production of monoamines and their metabolites in brain regions (rostral pallium, hypothalamus, brain stem, and midbrain) in broiler chickens submitted to chronic heat stress and/or infection and co-infection with Eimeria spp. and Clostridium perfringens type A. The heat stress and avian necrotic enteritis (NE) modulated the neurochemical profile of monoamines in different areas of the central nervous system, in particular, those related to the activity of the hypothalamus-hypophysis-adrenal (HPA) axis that is responsible for sickness behavior. C. perfringens and/or Eimeria infection, heat stress increased 5-hydroxytryptamine (5-HT), 4,4 dihydroxyphenylacetic acid (DOPAC), and DOPAC/dopamine (DA) in the rostral pallium; 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), homovanillic acid (HVA), HVA/DA, DOPAC/DA, and 5-hydroxyindoleacetic acid (5-HIAA)/5-HT in the hypothalamus; MHPG, 5-HIAA/5-HT, DOPAC/DA, and HVA/DA in the midbrain; and MHPG, DOPAC, HVA, HVA/DA, DOPAC/DA, and 5-HIAA/5-HT in the brainstem. Heat stress decreased noradrenaline + norepinephrine (NOR + AD) in all brain regions analyzed; 5-HT in the hypothalamus, midbrain, and brainstem; and DA in the midbrain. The results also showed the existence and activity of the brain-gut axis in broiler chickens. The brain neurochemical profile and corticosterone production are consistent with those observed in chronic stressed mammals, in animals with sickness behavior, and an overloading of the HPA axis.
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Published on May 1, 2016in Poultry Science 2.03
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
The gut-brain axis is known to modulate behavioral and immune responses in animals; evidence supporting this modulation in chickens, however, is elusive. Here, we analyzed the effects of heat stress and/orClostridium perfringens (CP) infection on behavior, intestinal morphology, brain activity, and corticosterone serum levels in chickens. Broilers were randomly divided into 5 equal groups: a naive group (N), a thioglycolate group (T), a thioglycolate heat-stressed group (T/HS35), an infected gro...
8 Citations Source Cite
Published on Mar 1, 2016in Veterinary Immunology and Immunopathology 1.85
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Adriana de Siqueira6
Estimated H-index: 6
(USP: University of São Paulo)
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract Avian necrotic enteritis (NE) induced by Clostridium perfringens is a disease that affects mainly the first weeks of poultry’s life. The pathogenesis of NE is complex and involves the combination of several factors, such as co-infection with different species of coccidia, immunosuppression and stress. Stress is one of the main limiting factors in poultry production. Although several studies emphasized the effects of stress on immunity, few works analyzed these effects on immunoglobulins...
8 Citations Source Cite
Published on Nov 2, 2015in Avian Pathology 1.96
Anderlise Borsoi2
Estimated H-index: 2
(USP: University of São Paulo),
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo)
+ 4 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
We analysed the effects of cold stress (19 ± 1°C, 6 h /day, from the first to the seventh day of life) applied to specific pathogen free (SPF) chickens. On experimental Day 1 (ED1), chicks were divided into four groups: C (not infected and kept under thermoneutral condition); CS (not infected and cold stressed); PC (Salmonella Heidelberg (SH) infected and kept under thermoneutral condition) and PCS (SH infected and cold stressed). High concentrations of corticosterone were found in the cold stre...
7 Citations Source Cite
Published on Jun 1, 2014in Poultry Science 2.03
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Bruno Takashi Bueno Honda3
Estimated H-index: 3
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
14 Citations Source Cite
Published on Jan 1, 2013in Neuroscience & Biobehavioral Reviews 8.00
David Chun-Hei Poon4
Estimated H-index: 4
(HKU: University of Hong Kong),
Ys Ho15
Estimated H-index: 15
(HKU: University of Hong Kong)
+ 1 AuthorsRaymond Chuen-Chung Chang42
Estimated H-index: 42
(HKU: University of Hong Kong)
Abstract Sickness refers to a set of coordinated physiological and behavioral changes in response to systemic inflammation. It is characterized by fever, malaise, social withdrawal, fatigue, and anorexia. While these responses collectively represent a protective mechanism against infection and injury, increasing lines of evidence indicate that over-exaggerated or persistent sickness can damage the brain, and could possibly raise the risk to developing delirium. Therefore, a clear understanding i...
34 Citations Source Cite
Published on Jul 1, 2011in Poultry Science 2.03
Kyung-Woo Lee23
Estimated H-index: 23
(ARS: Agricultural Research Service),
Hyun S. Lillehoj48
Estimated H-index: 48
(ARS: Agricultural Research Service)
+ 2 AuthorsDong-Jun An16
Estimated H-index: 16
(South Korean Ministry for Food, Agriculture)
The increasing trends of legislative restrictions and voluntary removal of antibiotic growth promoters worldwide has already affected, and will continue to affect, poultry production and animal health. Necrotic enteritis (NE) is being considered among the most important infectious diseases in the current poultry production system globally, with an estimated annual economic loss of more than $2 billion, largely attributable to medical treatments and impaired growth performance. Thus, there is an ...
67 Citations Source Cite
Published on Apr 1, 2011in NeuroImage 5.81
Hristina Jovanovic9
Estimated H-index: 9
(KI: Karolinska Institutet),
Aleksander Perski25
Estimated H-index: 25
(Stockholm University)
+ 1 AuthorsIvanka Savic37
Estimated H-index: 37
(KI: Karolinska Institutet)
There are increasing reports about stress related cognitive and psychic declines in subjects who have no psychiatric premorbidity, depression, or major life trauma. Yet, little is known about the u ...
64 Citations Source Cite
Published on Aug 1, 2009in Research in Veterinary Science 1.75
N.G. Gregory31
Estimated H-index: 31
(RVC: Royal Veterinary College),
Steven R. Payne7
Estimated H-index: 7
+ 1 AuthorsChristian J. Cook33
Estimated H-index: 33
Abstract The aim of this study was to assess whether environmental enrichment and environmental conditions can influence the expression of sickness behaviour. The behaviour in response to injection of lipopolysaccharide or saline was examined in a total of 96 62-weeks old hatchmate hens kept in a free range or cage environment. There were eight experimental treatments, each with 12 birds. Half the birds were sourced from a commercial cage layer unit (C/-) and half from a commercial free range un...
7 Citations Source Cite
Published on Mar 1, 2008in Avian Diseases 1.31
Soon S. Park1
Estimated H-index: 1
(ARS: Agricultural Research Service),
Hyun S. Lillehoj48
Estimated H-index: 48
(ARS: Agricultural Research Service)
+ 4 AuthorsErik P. Lillehoj42
Estimated H-index: 42
(UMB: University of Maryland, Baltimore)
SUMMARY. The incidence of necrotic enteritis (NE) due to Clostridium perfringens (CP) infection in commercial poultry has been increasing at an alarming rate. Although pre-exposure of chickens to coccidia infections is believed to be one of the major risk factors leading to NE, the underlying mechanisms of CP virulence remain undefined. The objectives of this study were to utilize an experimental model of NE produced by Eimeria maxima (EM) and CP coinfection to investigate the pathologic and imm...
86 Citations Source Cite
Published on Jan 1, 2008in Stress 2.17
Hideki Miura16
Estimated H-index: 16
(Nagoya University),
Norio Ozaki56
Estimated H-index: 56
(Nagoya University)
+ 3 AuthorsToshiharu Nagatsu75
Estimated H-index: 75
(Fujita Health University)
Alteration of tryptophan (TRP) metabolism elicited by proinflammatory cytokines has gained attention as a new concept to explain the etiological and pathophysiological mechanisms of major depression. The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase (IDO), is the main TRP metabolic pathway. It shares TRP with the serotonin (5-HT) pathway. Proinflammatory cytokines induce IDO under stress, promote the KYN pathway, deprive the 5-HT pathway of TRP, and reduce 5-HT synt...
108 Citations Source Cite
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