Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Abstract
Large studies use genotype data to discover genetic contributions to complex traits and infer relationships between those traits. Co-incident geographical variation in genotypes and health traits can bias these analyses. Here we show that single genetic variants and genetic scores composed of multiple variants are associated with birth location within UK Biobank and that geographic structure in genotype data cannot be accounted for using routine...
Paper Details
Title
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Published Date
Jan 18, 2019
Journal
Volume
10
Issue
1
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