Early preclinical detection of prions in the skin of prion-infected animals
Abstract
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensitive serial protein misfolding cyclic amplification (sPMCA) and real-time quaking-induced conversion (RT-QuIC) assays of skin samples from hamsters and humanized...
Paper Details
Title
Early preclinical detection of prions in the skin of prion-infected animals
Published Date
Jan 16, 2019
Journal
Volume
10
Issue
1
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