Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma
Abstract
Lung adenocarcinomas are characterized by mutations in the receptor tyrosine kinase (RTK)/Ras/Raf pathway, with up to 75% of cases containing mutations in known driver genes. However, the driver alterations in the remaining cases are yet to be determined. Recent exome sequencing analysis has identified SOS1, encoding a guanine nucleotide exchange factor, as significantly mutated in lung adenocarcinomas lacking canonical oncogenic RTK/Ras/Raf...
Paper Details
Title
Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma
Published Date
Apr 1, 2019
Journal
Volume
17
Issue
4
Pages
1002 - 1012
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