Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow
Abstract
Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individual target proteins. Here we explore an alternative approach based on pattern matching response profiles obtained using cultured neuronal networks. Conolidine and cannabidiol are plant-derivatives with known antinociceptive activity but unknown MOA. Application of conolidine/cannabidiol to cultured neuronal networks...
Paper Details
Title
Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow
Published Date
Jan 15, 2019
Journal
Volume
9
Issue
1
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