Original paper
Total synthesis, stereochemical assignment, and biological evaluation of L-755,807
Abstract
The relative and absolute configurations of L-755,807 were established through total synthesis. All four possible stereoisomers were prepared via a convergent synthetic strategy, including a novel diastereoselective Darzens reaction of an α-alkoxy aldehyde with di-tert-butyl bromomalonate, an E-selective Horner–Wadsworth–Emmons reaction, and late-stage coupling of the ring and side-chain segments. Additionally, biological evaluation of the...
Paper Details
Title
Total synthesis, stereochemical assignment, and biological evaluation of L-755,807
Published Date
Feb 1, 2019
Journal
Volume
75
Issue
8
Pages
1085 - 1097
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Notes
History