Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target

LAL is a checkpoint of intracellular lipid homeostasis that controls the amount of FC and FFAs released from the lysosome. LALD is characterized by massive accumulation of esterified cholesterol and triglycerides throughout the body, and in particular, in the liver and macrophages. LAL couples intracellular lipid metabolism to functions of the immune cells by providing FC and FFAs that are used for cell proliferation and acquisition of effector...