PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers
Abstract
Objective Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutations on the activity of afatinib, in this study we evaluate for the first time the role of oncogenic PIK3CA mutations as a potential mechanism of...
Paper Details
Title
PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers
Published Date
Apr 1, 2019
Journal
Volume
153
Issue
1
Pages
158 - 164
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