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Relation of the degree of obesity in childhood to adipose tissue insulin resistance

Published on Feb 1, 2019in Acta Diabetologica2.996
· DOI :10.1007/s00592-018-01285-3
Emilia Hagman7
Estimated H-index: 7
(HUJI: Hebrew University of Jerusalem),
Omri Besor1
Estimated H-index: 1
(Boston Children's Hospital)
+ 5 AuthorsRam Weiss34
Estimated H-index: 34
(Boston Children's Hospital)
Abstract
Aims In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR.
  • References (31)
  • Citations (1)
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References31
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#1Kálmán Bódis (HHU: University of Düsseldorf)H-Index: 6
#2Michael Roden (HHU: University of Düsseldorf)H-Index: 69
8 CitationsSource
#1Max C. Petersen (Yale University)H-Index: 11
#2Gerald I. Shulman (Yale University)H-Index: 144
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have ma...
55 CitationsSource
#1Gali Zabarsky (HUJI: Hebrew University of Jerusalem)H-Index: 1
#2Cherise Beek (HUJI: Hebrew University of Jerusalem)H-Index: 1
Last. Ram Weiss (HUJI: Hebrew University of Jerusalem)H-Index: 34
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Objective To compare cardiovascular risk factor clustering (CVRFC) in severely obese youth with those with lower degrees of obesity. Study design We divided a childhood obesity clinic derived cohort into the degrees of obesity (class I, II, and III) and added a “class IV” category corresponding to >160% of the 95th centile of body mass index (BMI) for age and sex. In a cross-sectional analysis, we investigated the presence of CVRFC in 2244 participants; in 621 who were followed longitudinally, w...
6 CitationsSource
#1Joon Young Kim (University of Pittsburgh)H-Index: 9
#2Alexis Nasr (University of Pittsburgh)H-Index: 4
Last. Silva A. Arslanian (University of Pittsburgh)H-Index: 64
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Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism in youth with prediabetes, the relationship between adipose tissue insulin sensitivity (ATIS) and β-cell function remains unknown. We investigated whole-body lipolysis, ATIS and β-cell function relative to ATIS [adipose disposition index (DI)] in obese youth with IGT vs. normal glucose tolerance (NGT). Whole-body lipolysis (glycerol appearance rate [GlyRa] ([2H5]glycerol at baseline and during a hyperinsulinemic-...
12 CitationsSource
#1Sonia Caprio (Yale University)H-Index: 65
#2Rachel J. Perry (Yale University)H-Index: 18
Last. Romy KursaweH-Index: 19
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As a consequence of the global rise in the prevalence of adolescent obesity, an unprecedented phenomenon of type 2 diabetes has emerged in pediatrics. At the heart of the development of type 2 diabetes lies a key metabolic derangement: insulin resistance (IR). Despite the widespread occurrence of IR affecting an unmeasurable number of youths worldwide, its pathogenesis remains elusive. IR in obese youth is a complex phenomenon that defies explanation by a single pathway. In this review we first ...
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#1Amalia Gastaldelli (University of Texas Health Science Center at San Antonio)H-Index: 66
#2Melania Gaggini (National Research Council)H-Index: 12
Last. Ralph A. DeFronzo (University of Texas Health Science Center at San Antonio)H-Index: 139
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In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However, the impact of dysfunctional adipose tissue has not been fully elucidated. The aim of this study was to evaluate the role of resistance to the antilipolytic effect of insulin (adipose tissue IR [Adipo-IR]) in a large group of subjects with NGT, impaired glucose tolerance (IGT), and T2DM. Three hundred two subj...
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#1Liping Luo (CSU: Central South University)H-Index: 1
#2Meilian Liu (CSU: Central South University)H-Index: 17
Abstract Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreove...
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#1Ulf Smith (University of Gothenburg)H-Index: 84
#2Barbara B. Kahn (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 111
Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces insulin resistance in peripheral insulin target tissues. Several mechanisms have been identified related to cross-talk between adipose tissue, skeletal muscle and liver. These mechanisms involve both increased free fatty acid release and altered secretion of adipokines from adipose tissue. A major determinant of metabolic health is the ability of subcutaneous adipose tissue (SAT) to store excess fat rather ...
73 CitationsSource
#1Emilia Hagman (KI: Karolinska Institutet)H-Index: 7
#2Pernilla Danielsson (KI: Karolinska Institutet)H-Index: 10
Last. Claude Marcus (KI: Karolinska Institutet)H-Index: 40
view all 5 authors...
Association between impaired fasting glycaemia in pediatric obesity and type 2 diabetes in young adulthood
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#1Karen Hershkop (HUJI: Hebrew University of Jerusalem)H-Index: 5
#2Omri Besor (HUJI: Hebrew University of Jerusalem)H-Index: 1
Last. Ram Weiss (HUJI: Hebrew University of Jerusalem)H-Index: 34
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Context: Adipocytes represent an important insulin-responsive tissue taking an active part in glucose metabolism. Objective: This study sought to assess adipose tissue insulin resistance (IR) across the spectrum of glucose tolerance and to test its relation with free fatty acid (FFA) suppression during an oral glucose tolerance test (OGTT). Design and Setting: A cross-sectional analysis of a pediatric clinic–derived cohort of obese adolescents. Patients or Other Participants: Participants age 7–...
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AIMS: Analyze the relationship between obesity and influenza. METHODS: Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral stra...
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#1Jiajia Jiang (Capital Medical University)H-Index: 2
#2Xueli Cai (WMU: Wenzhou Medical College)H-Index: 1
Last. Yan He (Capital Medical University)H-Index: 9
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Aims This study aimed to examine the association of different anatomical forms of obesity with adipose tissue insulin resistance and to assess the diagnostic value and contribution of obesity to adipose tissue insulin resistance. Methods This cross-sectional study included a total of 499 subjects aged 50 years or over. Multivariate regression analysis was conducted to clarify the association of different forms of obesity with adipose tissue insulin resistance (calculated as fasting insulin level...
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Adipose tissue is an active metabolic organ that contributes to processes such as energy storage and utilization and to the production of a number of metabolic agents, such as adipokines, which play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which can ...
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#1Ljiljana PlavsicH-Index: 2
#2Olivera M. Knezevic (University of Belgrade)H-Index: 6
Last. Prof.Dr. Djuro Macut (University of Belgrade)
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The aim of the study was to compare the effects of high-intensity interval training (HIIT) and nutrition advice on cardiometabolic biomarkers, hormonal parameters and cardiorespiratory fitness in a...
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