Mathematical model and computer simulations of telomere loss
Abstract
The molecular mechanisms that control the limited number of human cell divisions has occupied researchers ever since its first description in 1961. There is evidence that this limited growth capacity, referred to as cellular or replicative senescence, is the basis for organismal ageing. Numerous studies point to the molecular mechanisms of telomere involvement in this phenomenon. A hallmark of cell senescence is high stochasticity where...
Paper Details
Title
Mathematical model and computer simulations of telomere loss
Published Date
Mar 1, 2019
Volume
465
Pages
78 - 89
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