The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

The remarkable structural heterogeneity of chondroitin sulfate ( CS ) and dermatan sulfate ( DS ) generates biological information that can be unique to each of these glycosaminoglycans ( GAG s), and changes in their composition are translated into alterations in the binding profiles of these molecules. CS / DS can bind to various cytokines and growth factors, cell surface receptors, adhesion molecules, enzymes and fibrillar glycoproteins of the...