AB0418 The effect of concomitant methotrexate on serum tnf inhibitors levels and clinical response in patients with rheumatoid arthritis is dose dependent and greater than other dmards

Background

Several factors influence on the pharmacokinetics(PK) of TNF inhibitors(TNFi). One of the most relevant influencing factors is the development of antidrug- antibodies(ADA), which is associated with low circulating drug levels and loss of clinical efficacy. Previous studies, mostly about Adalimumab (Ada), have demonstrated a beneficial effect of concomitant use of methotrexate(MTX) in patients(pts) under TNFi therapy by...