TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
Abstract
Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnormalities and somatic mutations. To refine risk stratification of CK-MDS patients, we examined data from 359 CK-MDS patients shared by the...
Paper Details
Title
TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
Published Date
Jan 11, 2019
Journal
Volume
33
Issue
7
Pages
1747 - 1758
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