Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt
Abstract
The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C. elegans genome and identified 171 genes that, when knocked down, induce the expression of an hsp-6 HSP70 reporter and encode mitochondrial proteins. These genes represent many, but not all, mitochondrial processes (e.g., mitochondrial calcium homeostasis...
Paper Details
Title
Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt
Published Date
Aug 1, 2019
Journal
Volume
28
Issue
7
Pages
1659 - 1669.e5
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