Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification
Abstract
Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium tuberculosis. Streptococcal pathogens require dTDP-L-rhamnose for the production of structurally similar rhamnose polysaccharides in their cell wall. Via heterologous expression in S. mutans, we confirmed...
Paper Details
Title
Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification
Published Date
Jan 31, 2019
Journal
Volume
111
Issue
4
Pages
951 - 964
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