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Transcriptional regulation of lipid metabolism when salmon fry switches from endogenous to exogenous feeding

Published on Mar 1, 2019in Aquaculture3.022
· DOI :10.1016/j.aquaculture.2018.12.089
Yang Jin7
Estimated H-index: 7
(NTNU: Norwegian University of Science and Technology),
Rolf Erik Olsen29
Estimated H-index: 29
(NTNU: Norwegian University of Science and Technology)
+ 8 AuthorsYngvar Olsen5
Estimated H-index: 5
(NTNU: Norwegian University of Science and Technology)
Abstract
Abstract The onset of first feeding is a critical period for Atlantic salmon (Salmo salar). The fish goes through a dramatic transition, from using the yolk sac as an energy and nutrient resource to rely on exogenous food. However, the digestive system of salmon is not fully developed at start feeding. This is especially true for digestion and absorption of dietary lipids. To optimize lipid composition of the initial feed for better growth and development of salmon, it is important to have a systemic understanding of lipid metabolism. The present study combines transcriptomics and lipid composition data to obtain an overview of how lipid metabolism pathways change when salmon switch from endogenous to exogenous feed. Transition to exogenous feeding had higher influence on gene expression and fatty acids composition in pyloric caeca relative to liver, suggesting metabolism is more responsive in pyloric caeca when diet switches. The pathways of phospholipid and lipoprotein synthesis were both up-regulated in pyloric caeca, while phospholipid content unchanged. Because phospholipids are a major component of intestinal lipoproteins, it suggests that a higher level of dietary phospholipids is required for optimal lipid transport at first feeding stages. De-novo cholesterol synthesis pathway was up-regulated in pyloric caeca after exogenous feeding, while a down-regulation of bile acid synthesis pathway was found in liver. This suggests a higher requirement of cholesterol in salmon fry after switching to exogenous feeding. The present study has provided new insights on the systemic changes of lipid synthesis and transport pathways in salmon fry when switching from endogenous to exogenous feeding.
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#1Yang Jin (NTNU: Norwegian University of Science and Technology)H-Index: 7
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It has been suggested that the high phospholipid (PL) requirement in Atlantic salmon (Salmo salar) fry is due to insufficient intestinal de-novo synthesis causing low lipoprotein (LP) production and reduced transport capacity of dietary lipids. However, in-depth ontogenetic analysis of intestinal PL and LP synthesis with the development of salmon has yet to be performed. Therefore, in this paper we used RNA-Seq technology to investigate the expression of genes involved in PL synthesis and LP for...
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