Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone

Background Aberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D 2 antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression. Methods We recruited 43 medication-naïve subjects across the range of depression severity (Beck's...