CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Abstract
CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover, conventional mutation correction by gene-editing would only be relevant for the small fraction of neurodegenerative cases that are inherited. Here we introduce a CRISPR/Cas9-based strategy in cell and animal models to edit endogenous amyloid precursor protein (APP) at the extreme C-terminus and...
Paper Details
Title
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Published Date
Jan 3, 2019
Journal
Volume
10
Issue
1
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