H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Abstract
As an environment-dependent pleiotropic gene regulator in Gram-negative bacteria, the H-NS protein is crucial for adaptation and toxicity control of human pathogens such as Salmonella, Vibrio cholerae or enterohaemorrhagic Escherichia coli. Changes in temperature affect the capacity of H-NS to form multimers that condense DNA and restrict gene expression. However, the molecular mechanism through which H-NS senses temperature and other...
Paper Details
Title
H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Published Date
Dec 28, 2018
Journal
Volume
47
Issue
5
Pages
2666 - 2680
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