Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response
Abstract
More than half of cancer patients receive radiotherapy as a part of their cancer treatment. DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage and a primary cause of cell death and are induced by ionizing radiation (IR) during radiotherapy. Many malignant cells carry multiple genetic and epigenetic aberrations that may interfere with essential DSB repair pathways. Additionally, exposure to IR induces the...
Paper Details
Title
Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response
Published Date
Jan 4, 2019
Journal
Volume
10
Issue
1
Pages
25 - 25
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