Resveratrol protects against early cardiomyopathic changes-induced by Type-1 diabetes through a heme-oxygenase-1 dependent mechanism

Diabetes can be considered as a state of chronic inflammation and oxidative stress. Excessive oxidative stress is implicated in the pathogenesis of all diabetic complications. Heme oxygenase-1 is an antioxidant enzyme that is upregulated in response to a variety of insults as a protective mechanism. Resveratrol (RSV) is a polyphenol that exhibits promising pharmacological effects in a variety of disease models. In this study, we investigated the...