Multiple Roles for Mono- and Poly(ADP-Ribose) in Regulating Stress Responses

DNA damage promotes the rapid production of pADPr chains on damaged chromatin and is crucial for initiating recruitment of DNA repair proteins. pADPr then undergoes rapid (seconds to minutes) degradation by PARG and related enzymes, releasing mADPr and soluble pADPr molecules into the nucleoplasm and cytoplasm. Many stress-response proteins contain ADP-ribose-binding modules with specificity for mADPr or pADPr, such that binding of specific...