The Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank
Abstract
Objective: Schizophrenia is associated with a marked reduction in reproductive success, yet alleles that are common contribute substantially to the liability of the disorder. Among several possible explanations for this, it has been postulated that individuals who carry risk alleles but are unaffected are at some reproductive advantage, offsetting the effects of negative selection among those who are affected. The authors sought to test this...
Paper Details
Title
The Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank
Published Date
Aug 1, 2019
Volume
176
Issue
8
Pages
661 - 666
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